Lyophilization
Click here to view our 8 minute BOC Edwards 200 ft2 lyophilization video.
Small Volume Parenterals
HollisterStier has two BOC Edwards 200 ft2 lyophilizers available for both clinical and commercial scale projects. This automatic loading lyophilizer is one of the few lyophilizers in the world designed to accommodate sensitive pharmaceutical liquid products. Products that require loading onto pre-frozen shelves at temperatures as low as -55°C can be accomplished with this lyophilizer. HollisterStier, in collaboration with BOC Edwards Pharmaceutical Systems, has designed a low humidity (down to 5% RH) and low temperature custom environment (10-12°C) in the vial loading area to eliminate concerns with frost build-up on the shelves.
 The lyophilizer operates using state-of-the-art software allowing the system to be fully automatic. The automatic features include a Clean-in-Place (CIP) system and a Steam-in-Place (SIP) system, integrity testing of dual sterile filters, batch record generation, and an automatic load and unload system. Vials are processed and filled using HollisterStiers existing high-speed parenteral manufacturing line. Upon filling and partial stoppering of the vials, they are automatically conveyed to a clean room complex under ISO5 (class 100) conditions. The automatic loading system on the lyophilizer then loads the vials at speeds up to 200 vials per minute. The vial sizes can range from 2mL to approximately 125mL. Vial capacity is dependent upon vial dimensions. Contact HollisterStier for further information regarding vial capacity.
Lyophilization—Small Lot Manufacturing
Edwards Lyofast S20 Lyophilizer Specifications
Within HollisterStier's SLM area is an Edwards 30ft2 lyophilizer. This lyophilizer is available for both clinical and commercial scale projects. The 30ft2Edwards consists of 5 moveable shelves, and an external condenser with redundant refrigeration compressors and an automated CIP/SIP system. Vial capacity is dependent upon vial dimensions. Contact HollisterStier for further information regarding vial capacity.
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